Наредни састанак Семинара биће одржан онлајн у среду, 23.марта 2022, са почетком у 18.15 часова.
Предавачи: др Марија Радмиловић-Рађеновић, др Бранислав Рађеновић, Институт за физику
Наслов предавања: NUMERICAL SIMULATIONS OF MICROWAVE LIVER TUMOR ABLATION
Апстракт: Hepatocellular carcinoma accounts for around 75% of all liver cancers, and represents the fourth most common cause of cancer-related deaths. Microwave ablation is a well esatblished treatment of hepatocellular carcinoma. The success rate for completely eliminating small liver tumors in patients treated with microwave ablation isgreater than 85%. Microwave ablation is also highly recommended for COVID-19 patients with liver tumors as a fast treatment with a short recovery time. The involvement of the temperature dependence of the heat capacity, the thermal conductivity, and blood perfusion, is pivotal for establishing the correct ablation process and preserving the healthy tissue.
Every mathematical model for the simulation of microwave ablation consists of three fundamental components. The first component is the model of the antenna probe (or applicator) that generates a microwave field in the tissue. The antennas are usually mechanically and geometrically complex, and the simulation relies on having accurate electromagnetic material and tissue properties. In this study, we use a compact 10-slot microwave antenna with an impedance pi-matching network that creates near-spherical ablation zones. The second component describes the heat distribution in the tissue including sources and sinks and the phase changes. Heat transfer during the MWA process can be accurately described by the Pennes bioheat equation. In our case, the microwave field is the source of heat, and the heat sinks are represented by the blood perfusion term in the heat transfer equation. The third part deals with the effect of heat on tumor cells and their destruction. All these components of the ablation model depend on a variety of material parameters, which themselves depend on the various states of the tissue. Finally, to define realistic simulation model, we were using the data from the 3D-IRCADb-01 database of hepatocellular carcinoma.
The 3D finite elements method (FEM) is used to solve coupled electromagnetic-field and heat-transfer equations, including all details of antenna design and properties of healthy and tumoral tissue. Our 3D model is created within the COMSOL Multiphysics FEM-based simulation platform.
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